Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 155-158.doi: 10.3969/j.issn.1673-8225.2011. 01.035

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Functional characteristics of promyelocytic leukemia protein isoforms 

Zhao Liang, Zhang Xue-mei   

  1. Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2010-09-15 Revised:2010-10-10 Online:2011-01-01 Published:2011-01-01
  • Contact: Zhang Xue-mei, Master, Associate professor, Chief physician, Master’s supervisor, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China zxm8955@sohu.com
  • About author:Zhao Liang★, Studying for master’s degree, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China zhaol.168@163.com

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Abstract:

BACKGROUND: Each isomer of promyelocytic leukemia protein is various due to different structural domain sequence at C terminal, but the effects of each isomer remain unclear.
OBJECTIVE: To retrospectively analyze the genetic transcription regulation, cell growth differentiation, cell apoptosis, immune reaction and its karyosome formation of promyelocytic leukemia protein isomer.
METHODS: The first author retrieved PubMed Database and FMJS Database for articles concerning wildtype promyelocytic leukemia protein, promyelocytic leukemia protein karyoplast, function as well as structure, naming and function of promyelocytic leukemia protein isomer and their interaction published from 1992 to 2010.
RESULTS AND CONCLUSION: Promyelocytic leukemia protein gene was expressed as potentially many alternatively spliced mRNAs, each of which encodes a distinct protein i.e. promyelocytic leukemia protein isoform. As each promyelocytic leukemia protein isoform shares an identical N-terminal region, which decides they have general character in certain function, such as cell apoptosis. However, all isoforms of promyelocytic leukemia protein differ from one another by C-terminal domain, which decides that each promyelocytic leukemia protein isoform has respective character in certain function, such as intrinsic antiviral activities, cell growth and differentiation. Further studies will be required to explore the concrete biochemistry mechanism of the function of varied isoforms.

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